Prostaglandin intermediates and their synthesis

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 307/77 (2006.01)

Patent

CA 2557401

An improved method of the preparation of intermediates of high enantiomeric purity, useful for synthesis of prostaglandins, is provided. Protected prostaglandin intermediates requiring substantial chiral purity at position 15 are prepared from a mixture of stereoisomers by specific fractional crystallization techniques, to obtain an S--stereoisomer in a purity of 99.5 % or greater.

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