Prostaglandin-lipid formulations

Details Prostaglandin-lipid formulations Prostaglandin-lipid formulations

A - Human Necessities

61

K

167/163, 167/263

A61K 31/557 (2006.01) A61K 9/127 (2006.01) A61K 31/5575 (2006.01)

Patent

CA 1323838

PROSTAGLANDIN-LIPID FORMULATIONS ABSTRACT A liposome composition and methods for making same are disclosed, such compositions comprise an arachidonic acid metabolite such as a prostaglandin, preferably prostaglandin R1, a lipid and a drying protectant such as a saccharide. The liposomes may be loaded with prostaglandin passively, or using a transmembrane concentration gradient, preferably using a transmembrane pH gradient. Using this transmembrane loading technique, trapping efficiencies of 50% to 100% are achieved, and the release rate of the prostaglandin from the liposomes is reduced The liposome size is maintained after lypophilization and reconstruction.

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