C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 405/00 (2006.01) C07D 309/12 (2006.01)
Patent
CA 2549056
A process for the preparation of prostaglandin compounds having the formula (I); wherein A is selected from the group consisting Of C1-C6 alkyl; C7-C16 aralkyl wherein the aryl group is optionally substituted with one to three substituents selected from the group consisting Of C1 -C6 alkyl, halo and CF3; and (CH2)nOR' wherein n is from 1 to 3 and R' represents a C6-Cl0 aryl group which is optionally substituted with one to three substituents selected from the group consisting Of C1-C6 alkyl, halo and CF3; B is selected from OR" and NHR" wherein R" is C1-C6 alkyl; and formula (a) represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.
L'invention concerne un procédé de préparation de composés de la prostaglandine de la formule (I), dans laquelle A est choisi dans le groupe formé de C¿1?-C¿6? alkyle; C¿7?-C¿16? aralkyle, le groupe aryle étant éventuellement substitué avec un jusqu'à trois substituants choisis dans le groupe formé de C¿1?-C¿6? alkyle, halo et CF¿3?; et (CH¿2?)¿n?OR', n étant compris entre 1 et 3 et R' représentant un groupe C¿6?-C¿10? aryle éventuellement substitué avec un à trois substituants choisis dans le groupe formé de C¿1?-C¿6? alkyle, halo et CF¿3?. B est choisi parmi OR'' et NHR'', R'' représentant C¿1?-C¿6? alkyle; et ----- représente une double liaison ou une liaison simple. L'invention concerne également de nouveaux intermédiaires.
Clissold Derek Wyndham
Craig Stuart Wilbert
Gadikota Rajendrakumar Reddy
He Min
Jurayj Jurjus Fayez
Johnson Matthey Public Limited Company
Ridout & Maybee Llp
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