Prostaglandin synthesis and intermediates for use therein

Details Prostaglandin synthesis and intermediates for use therein Prostaglandin synthesis and intermediates for use therein

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) C07C 405/00 (2006.01) C07D 307/935 (2006.01) C07D 311/94 (2006.01)

Patent

CA 2639240

Fused cyclopentane - 4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: (see formula A) wherein R represents an aryl group such as p-methoxyphenyl. This compound can be reacted with a lower alkyl aluminum compound to open the dioxalane ring and reduce the lactone to lactol, without over-reducing to diol. The resulting compound can be functionalized to insert chemical side groups of target prostaglandins, adding the required .alpha.-side chain and then the required .omega.-side chain sequentially and independently of each other. The compounds and process are particularly suitable for preparing lubiprostone.

Affiliated with

Also associated with

Rating

Prostaglandin synthesis and intermediates for use therein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prostaglandin synthesis and intermediates for use therein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prostaglandin synthesis and intermediates for use therein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1812424