Prostaglandins of the d series, and tranquilizers and...

Details Prostaglandins of the d series, and tranquilizers and... Prostaglandins of the d series, and tranquilizers and...

C - Chemistry, Metallurgy

07

C

167/205, 260/235

C07C 405/00 (2006.01) A61K 31/557 (2006.01)

Patent

CA 1322749

- 1 - Abstract The present invention provides novel prostaglandins of the D series, that is 13,14-dihydro-15-keto-PGDs of the formula Image (I) wherein (X) is (A) Image , (B) Image , Image , (C) (D) Image R1 is hydrogen, physiologically acceptable salt Thor, physiologically acceptable protective group or C1-4 alkyl; R2 is hydrogen or methyl; R3 is hydroxyl, methyl or hydroxymethyl; R4 and R5 may be the same or different and represent hydrogen, methyl, hydroxyl or halogen; R5 is C1-9 alkyl which may be branched or contain a double bond or C1-9 alkyl containing an ether substituent wherein carbons at the 2 - 3 position may have a double bond, except when R1, R2, R4 and R5 are hydrogen, R3 is hydroxyl, R6 is n-butyl, carbons at 2 - 3 positions are singly bonded, and (X) is A, C, or D.

557480

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