Prostane derivatives

Details Prostane derivatives Prostane derivatives

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 213/60 (2006.01) C07C 405/00 (2006.01) C07D 309/12 (2006.01)

Patent

CA 1152503

ABSTRACT PROSTANE DERIVATIVES The disclosure relates to 9.beta.-aryloxy prostane derivatives, for example 16-(3-chloro- phenoxy)-11.alpha.,15.alpha.-dihydroxy-16-methl-9.beta.-phenoxy- 18,19,20-trinor-5-cis,13-trans-prostadienoic acid, which possess high activity as abortifacients, cervical softeners, inducers of parturition or inhibitors of gastric acid production in mammals. These properties are typical of prostaglandin analogues of the E series, but chemically the new 9.beta.-aryloxy prostane derivatives are prostaglandin F series analogues and are therefore more stable than the E series analogues previously used for the above purposes, The new derivatives are manufactured by known analogy processes, and are formulated in conventional manner.

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