C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C12N 15/11 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2484845
The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates to methods of detecting and treating prostate cancer, comprising modulating or detecting PCADM-1 expression and/or production and activity of PCADM-1 polypeptide. Further, the invention relates to novel assays for the identification of DNA-binding proteins and the double- stranded oligonucleotide sequences that specifically bind with them. Finally, the invention relates to DNAZYMs or DNA enzymes which specifically bind PCADM- 1 mRNA to inhibit PCADM-1 gene expression and thereby destroy tumor cells and tumor tissue.
L'invention concerne de nouveaux acides nucléiques codant un gène PCADM-1 de mammifère, et des protéines codées par ce gène, dont l'expression est accrue dans certaines maladies, dans certains troubles ou dans certains états pathologiques, comprenant, de manière non exhaustive, le cancer de la prostate. L'invention concerne des méthodes de détection et de traitement du cancer de la prostate, consistant à moduler ou à détecter l'expression de PCADM-1 et/ou la production et l'activité du polypeptide PCADM-1. En outre, l'invention concerne de nouveaux essais pour l'identification de protéines se liant à l'ADN et de séquences oligonucléotidiques bicaténaires se liant spécifiquement à ces protéines. Enfin, l'invention concerne des DNAZYM ou des enzymes d'ADN se liant spécifiquement à l'ARNm de PCADM-1 pour inhiber l'expression du gène PCADM-1, et par conséquent pour détruire des cellules tumorales et du tissu tumoral.
Hu Youji
Stearns Mark
Wang Min
Gowling Lafleur Henderson Llp
Philadelphia Health And Education Corporation (d/b/a/ Mcp Hahnem
LandOfFree
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