C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2664630
The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The disclosure further provides therapeutic compositions and methods of detecting, diagnosing, prognosing, and treating prostate cancer, including biomarkers for detecting the expression of two or more of the following genes: PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG.
L'invention décrit des altérations de l'expression du gène ERG. Sont fournies des isoformes d'ERG et une séquence de promoteurs du gène ERG impliqués dans le cancer de la prostate ou associés à celui-ci. L'invention fournit en outre des compositions thérapeutiques et des procédés pour détecter, diagnostiquer, pronostiquer et traiter un cancer de la prostate, y compris des biomarqueurs pour détecter l'expression de deux des gènes suivants ou plus :PSA/KLK3, PMEPM, NKX3.1, ODC1, AMD1, et ERG.
Dobi Albert
Petrovics Gyorgy
Sreenath Taduru
Srivastava Shiv
Sun Chen
Dobi Albert
Kirby Eades Gale Baker
Petrovics Gyorgy
Sreenath Taduru
Srivastava Shiv
LandOfFree
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