Prostate-specific membrane antigen

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 51/10 (2006.01) C07K 1/22 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2147499

This invention provides for an isolated mammalian nucleic acid molecule encoding a mammalian prostate-specific membrane antigen. This invention provides for nucleic acid probes which specifically hybridize with the nucleic acid molecule encoding said antigen. This invention provides for a method of detecting hematogenous micrometastic tumor cells of a subject performing the polymerase chain reaction (PCR) on samples of the subjet using primers of said antigen. This invention provides for methods to identify ligands which bind to said antigen. This invention provides for the prevention and/or treatment of prostate tumor growth.

La présente invention concerne : une molécule d'acide nucléique de mammifère isolée, codant un antigène membranaire spécifique de la prostate; des sondes d'acides nucléiques qui se lient de façon spécifique à la molécule d'acide nucléique codant ledit antigène; une méthode permettant de détecter les cellules tumorales micrométastatiques hématogènes chez un sujet, laquelle consiste à soumettre des échantillons prélevés chez le sujet à une amplification par la polymérase (PCR) en utilisant des amorces dudit antigène; et des méthodes permettant d'identifier les ligands qui se lient audit antigène. La présente invention a pour objet la prévention et/ou le traitement de la croissance des tumeurs prostatiques.

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