Prostate-specific membrane antigen and uses thereof

Details Prostate-specific membrane antigen and uses thereof Prostate-specific membrane antigen and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 49/00 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2212846

This invention provides an isolated mammalian nucleic acid molecule encoding an alternatively spliced prostate-specific membrane (PSM') antigen. This invention provides an isolated nucleic acid molecule encoding a prostate- specific membrane antigen promoter. This invention provides a method of detecting hematogenous micrometastic tumor cells of a subject, and determining prostate cancer progression in a subject.

Cette invention concerne une molécule d'acide nucléique de mammifère et codant pour un antigène membranaire spécifique de la prostate dénommé PSM' qui est une variante de l'antigène PSM. Cette invention concerne également des molécules d'acides nucléiques isolées, codant pour un promoteur d'antigène spécifique de la prostate. Cette invention concerne également une méthode permettant de détecter des cellules cancéreuses de micrométastases hématogènes chez un sujet et de suivre la progression d'un cancer de la prostate chez ce dernier.

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