C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2300364
The present invention is directed to novel polynucleotides and the polypeptides encoded by them, each of which are specific to human prostate tumor cells. The present invention further provides chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, and antibodies which bind to the polypeptides of the present invention. Also provided herein are methods for producing the polypeptides of the present invention, as are detection assays that detect the presence of tumor cells in tissue or bodily fluid samples and methods for identifying novel compositions which modulate the activity of prostate tumor antigens and the use of such compositions in diagnosis and treatment of disease.
La présente invention concerne des polynucléotides et les polypeptides codés par ces polynucléotides, lesquels polynucléotides et polypeptides sont spécifiques des cellules tumorales de la prostate de l'homme. L'invention concerne également, d'une part des molécules polypeptides chimériques comprenant les polypeptides de l'invention fusionnés à des séquences de polypeptides hétérologues, et d'autre part des anticorps se liant aux polypeptides de la présente invention. L'invention concerne en outre des procédés de production de ces polypeptides, ainsi que des dosages de détection permettant de détecter la présence de cellules tumorales dans des prélèvements de tissus ou de fluides anatomiques, et enfin des procédés permettant d'identifier des compositions de l'invention modulant l'activité des antigènes de tumeurs de la prostate et l'utilisation de telles compositions pour le diagnostic et le traitement d'une pathologie.
Laus Reiner
Shapero Michael H.
Tsavaler Larisa
Dendreon Corporation
Gowling Lafleur Henderson Llp
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