Prosthesis having varied concentration of beneficial agent

Details Prosthesis having varied concentration of beneficial agent Prosthesis having varied concentration of beneficial agent

A - Human Necessities

61

F

A61F 2/06 (2006.01) B05C 5/02 (2006.01) B05C 13/02 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2505367

An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The interventional device has a controlled local areal density of beneficial agent for systemic delivery or delivery to the luminal wall. The local areal density of beneficial agent may be varied along the prosthesis. The interventional device includes overlapping or bifurcated stents having a controlled areal density of beneficial agent.

L'invention concerne un dispositif interventionnel destiné à l'acheminement d'un agent utile vers une lumière, et des procédés de chargement et de fabrication du dispositif. Le dispositif comprend une prothèse chargée d'un agent utile pour fournir à ladite lumière une concentration de dosage régulée d'un agent utile. L'agent utile est chargé sur la prothèse par un distributeur de liquide comprenant un élément de distribution pouvant distribuer l'agent utile en gouttelettes discrètes, chaque gouttelette suivant une trajectoire contrôlée. Le dispositif interventionnel présente une densité spatiale locale régulée d'un agent utile pour le transport systémique ou l'acheminement vers la paroi intracavitaire. La densité spatiale locale de l'agent utile peut être variée le long de la prothèse. Le dispositif interventionnel comprend des tuteurs superposés ou bifurqués présentant une densité locale régulée de l'agent utile.

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