Prosthetic grafts

Details Prosthetic grafts Prosthetic grafts

A - Human Necessities

61

L

A61L 27/40 (2006.01) C12N 5/071 (2010.01) A61F 2/06 (2006.01) A61L 27/38 (2006.01) A61L 27/56 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2368253

An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The adherent cells are transfected with at least one recombinant nucleic acid molecule encoding at least one protein that enhances patency of the graft. The prosthetic graft has a long-term patency and success rate that is superior to other previously described prosthetic grafts designed for such use. Also disclosed are methods of making and using such a graft.

Greffe prothétique améliorée permettant de contourner, remplacer ou réparer des vaisseaux et des organes en contact avec la circulation sanguine. Cette greffe comprend un implant prothétique poreux et des cellules adhérant à la surface extérieure de cet implant. Ces cellules adhésives sont transfectées par au moins une molécule d'acide nucléique de recombinaison codant au moins une protéine augmentant la perméabilité de la greffe. Cette dernière présente une perméabilité à long terme et son taux de réussite est supérieur à celui des greffes prothétiques de ce type utilisées actuellement. L'invention concerne également des procédés d'élaboration et de mise en application de cette greffe.

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