Protamine-adenoviral vector complexes and methods of use

Details Protamine-adenoviral vector complexes and methods of use Protamine-adenoviral vector complexes and methods of use

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2479759

Embodiments of the invention include methods and compositions including viral composition that have high transduction efficiencies in vivo, in vitro and ex vivo. The viral composition include a viral vector and a protamine molecule, wherein the viral vector includes a polynucleotide encoding a tumor suppressor gene. The methods of the invention include administering the viral composition to a patient or subject for treatment of disease, in particular cancer, that is characterized by a reduced vector-induced production of neutralizing antibodies and a decreased vector-induced toxicity as compared to delivery of viral vectors alone.

Dans des modes de réalisation, l'invention concerne des procédés et des compositions, y comprise une composition virale, possédant des efficacités élevées de transduction <i>in vivo, in vitro </i> et <i>ex vivo </i>. La composition virale comprend un vecteur viral et une molécule de protamine, ce vecteur viral comprenant un polynucléotide codant pour un gène suppresseur de tumeur. Les procédés de l'invention consistent à administrer la composition virale à un patient ou à un sujet pour le traitement d'une maladie, en particulier du cancer, cette administration étant caractérisée par la production réduite, induite par le vecteur, d'anticorps neutralisants et une toxicité réduite, induite par le vecteur, en comparaison de l'administration de vecteurs viraux seuls.

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