C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) C12M 1/40 (2006.01) G01N 27/333 (2006.01)
Patent
CA 2153627
A polymeric membrane electrode gives potentiometric responses to macromole- cules, such as protamine, in solution or biological specimens. A protamine-responsive membrane includes a lipophilic cation-exchange material for ionic macromolecules in a specially formulated plasticized, polymeric matrix material. Potentiometric response to protamine has been observed in membranes comprising 30-70 wt.% polymeric matrix material, such as polyvinyl chloride; 1-3 wt.% salt of a tetraphenylborate, such as potassium tetrakis(4-chlorophenyl) borate or salt of an organophosph(on)ate, such as calcium bis-[4-(1,1,3,3-tetramethylbutyl)phenyl] phosphate; and 30-70 wt.% of a plasti- cizer, such as 2-nitrophenyl octyl ether or tris (2-ethylhexyl) phosphate. The potentio- metric response of these membranes to protamine can be used to study the binding inter- action of protamine with heparin (both native and low molecular fractions) or to monitor protease activity, for example, by following the rate of degradation of intact protamine or a synthetic substrate by trypsin, as well as to measure protamine concentration in bio- logical fluids, such as blood or plasma.
Meyerhoff Mark E.
Yang Victor C.
Yun Jong Hoon
Meyerhoff Mark E.
Smart & Biggar
The Board Of Regents Acting For And On Behalf Of The University
Yang Victor C.
Yun Jong Hoon
LandOfFree
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