Protease and process for production and use thereof

Details Protease and process for production and use thereof Protease and process for production and use thereof

C - Chemistry, Metallurgy

12

N

195/128, 195/33.

C12N 9/60 (2006.01) C12P 21/06 (2006.01)

Patent

CA 1247024

NEW PROTEASE AND PROCESS FOR PRODUCTION AND USE THEREOF ABSTRACT OF THE DISCLOSURE Disclosed is a new protease having the following properties: (1) it is able to hydrolitically cleave a peptide bond between two adjacent basic amino acids in a peptide chain; (2) it has a molecular weight of about 43,000 as determined by electrophoresis; (3) it is inhibited by phenylmethylsulphonyl fluoride and diisopro- pyl fluorophosphate, but is not inhibited by monoiodo- acetate, p-chloromercuribenzoic acid, ethylenediamine- tetraacetic acid, 1,10-phenanthroline, tosyl-L-lysine chloromethyl ketone, and leupeptin. The protease can be produced by culturing Saccharomyces cerevisiae, and recovering purification by conventional methods, and is useful as a processing enzyme for conversion of a prohormone to an active hormone.

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