Protease conjugates

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/195 (2006.01) A61K 8/66 (2006.01) C07K 17/06 (2006.01) C07K 17/08 (2006.01) C07K 19/00 (2006.01) C11D 3/00 (2006.01) C11D 3/386 (2006.01) C12N 9/54 (2006.01)

Patent

CA 2324506

The present invention relates to subtilisin protease conjugates comprising a protease moiety and one or more addition moieties wherein the protease moiety has a modified amino acid sequence of a parent amino acid sequence, the parent amino acid sequence comprising a first epitope region, a second epitope region, and a third epitope region, wherein the modified amino acid sequence comprises a substitution by a substituting amino acid at one or more positions in one or more of the epitope regions and wherein each addition moiety is covalently attached to one of the substituting moieties. The present invention further relates to cleaning and personal care compositions comprising such protease conjugates.

L'invention concerne des conjugués de subtilisine protéase comprenant une fraction de protéase et une ou plusieurs fractions d'addition, la fraction de protéase présentant une séquence d'acide aminé modifié d'une séquence d'acide aminé parent. La séquence d'acide parent comprend une première région épitope, une seconde région épitope et une troisième région épitope. La séquence d'acide aminé modifié comprend une substitution par un acide aminé de substitution, à une ou plusieurs positions, dans une ou plusieurs régions épitopes, et chaque fraction d'addition est fixée, de manière covalente, à l'une des fractions de substitution. L'invention concerne, en outre, des compositions de nettoyage et de soins personnels comprenant ces conjugués de protéase.

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