Protease conjugates having sterically protected clip sites

Details Protease conjugates having sterically protected clip sites Protease conjugates having sterically protected clip sites

C - Chemistry, Metallurgy

12

N

C12N 9/54 (2006.01) C11D 3/386 (2006.01)

Patent

CA 2379729

The present disclosure relates to subtilisin protease conjugate comprising a protease moiety and one or more addition moieties. Each addition moiety is covalently attached to a clip site protection position of the protease moiety, wherein the clip site protection positions are selected from 13, 14, 15, 16, 18, 19, 20, 21, 84, 85, 88, 158, 159, 160, 161, 162, 163, 164, 165, 170, 186, 191, 192, 193, 194, 196, 259, 260, 261, 262, and 274 corresponding to subtilisin BPN'. The protease conjugates have decreased immunogenicity relative to a parent protease. The present disclosure further relates to cleaning and personal care compositions comprising the protease conjugates.

L'invention concerne des conjugués de subtilisine protéase comprenant une fraction de protéase et une ou plusieurs fractions d'addition. Chaque fraction d'addition est liée par covalence à un site clip (site d'hydrolyse in vivo) protégé de la fraction de protéase, les positions de protection des sites clip étant choisies parmi (13, 14, 15, 16, 18, 19, 20, 21, 84, 85, 88, 158, 159, 160, 161, 162, 163, 164, 165, 170, 186, 191, 192, 193, 194, 196, 259, 260, 261, 262 et 274) correspondant à la subtilisine BPN'. Ces conjugués de protéase présentent une immunogénicité réduite par rapport à une protéase apparentée. L'invention concerne également des compositions de nettoyage et de soins personnels comprenant ces conjugués de protéase.

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