Protease conjugates having sterically protected epitope regions

Details Protease conjugates having sterically protected epitope regions Protease conjugates having sterically protected epitope regions

C - Chemistry, Metallurgy

12

N

C12N 9/54 (2006.01) C11D 3/386 (2006.01) C12N 9/96 (2006.01)

Patent

CA 2379723

The present disclosure relates to subtilisin protease conjugate comprising a protease moiety and one or more addition moieties. Each addition moiety is covalently attached to an epitope protection position of the protease moiety. The protease conjugates have decreased immunogenicity relative to a parent protease. The present disclosure further relates to cleaning and personal care compositions comprising the protease conjugates.

L'invention concerne des conjugués de subtilisine protéase comprenant une fraction de protéase et une ou plusieurs fractions d'addition. Chaque fraction d'addition est liée par covalence à une position épitope protégée de la fraction de protéase. Ces conjugués de protéase présentent une immunogénicité réduite par rapport à une protéase apparentée. L'invention concerne également des compositions de nettoyage et de soins personnels comprenant ces conjugués de protéase.

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