Protease-free proteins, and methods of manufacturing and...

C - Chemistry – Metallurgy – 12 – N

Patent

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167/104, 195/123

C12N 15/57 (2006.01) A61K 38/00 (2006.01) C12N 9/48 (2006.01) C12N 9/64 (2006.01)

Patent

CA 1053661

Abstract Protease-free proteins, especially protease-free kallikrein, are prepared by contacting a solution of the protein with a carrier-bound water-insoluble protease inhibitor that does not bind to said protein. The protease-free proteins have improved storage stability in solution, and are used therapeutically for the same purposes as the protein before treatment according to the invention.

233663

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