Protease inhibitor and process for producing it

Details Protease inhibitor and process for producing it Protease inhibitor and process for producing it

C - Chemistry, Metallurgy

12

N

530/7.1, 195/1.2

C12N 15/15 (2006.01) C07K 14/81 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2025537

- 18 - ABSTRACT The present invention relates to methionine trypstatin which is a novel protease inhibitor, a gene encoding its amino acid sequence, a plasmid containing this gene, a microorganism transformed by the plasmid and a process for producing methionine trypstatin using the microorganism. Trypstatin, which has not previously been produced by microorganisms, is produced as methionine trypstatin using a microorganism, by adding methionine to the N terminus of trypstatin, selecting the appropriate DNA from all DNAs that the microorganism can produce, and constructing the plasmid. Methionine trypstatin is promising as an agent for the treatment or prevention of nephritis, chronic articular rheumatism, liver cirrhosis, or other conditions in which tryptase participates.

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