C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/18 (2006.01) A61K 31/341 (2006.01) A61K 31/427 (2006.01) A61K 31/435 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/513 (2006.01) A61K 38/38 (2006.01) A61K 38/42 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) A61P 31/12 (2006.01) C07D 277/28 (2006.01) C07D 401/14 (2006.01) C07D 417/14 (2006.01) C07K 14/765 (2006.01) C07K 14/805 (2006.01) C07K 16/00 (2006.01) C07K 16/38 (2006.01) C07K 16/44 (2006.01) C12N 5/12 (2006.01)
Patent
CA 2449243
Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir and lopinavir.
L'invention concerne des haptènes activés utiles pour produire des immunogènes contre les inhibiteurs de protéase du VIH, des immunogènes utiles pour produire des anticorps dirigés contre les inhibiteurs de protéase du VIH, ainsi que des anticorps et des conjugués marqués utiles dans des dosages immunologiques d'inhibiteurs de protéase du VIH. Ces nouveaux haptènes comportent une fonctionnalité activée au groupe hydroxyle central non terminal commun à tous les inhibiteurs de protéase du VIH, p. ex. saquinavir, nelfinavir, indinavir, amprenavir, ritonavir et lopinavir.
Deras Ina
Ghoshal Mitali
Huber Erasmus J.
Hui Raymond
Metz Sigrun
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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