Protease inhibitors

Details Protease inhibitors Protease inhibitors

C - Chemistry, Metallurgy

12

P

530/5.02, 530/7.

C12P 21/02 (2006.01) C07K 5/02 (2006.01) C12N 9/99 (2006.01)

Patent

CA 1159000

ABSTRACT OF THE DISCLOSURE A novel accumulated product is produced herein from a novel microorganism. By this invention, a process is provided for producing at least one procidin of the general formula: Image wherein R1 and R2, which may either be identical or different, represent isopropyl or isobutyl; and R4 represents hydrogen, carboxyl or methyl carboxylate when both, R1 and R2 are isopropyl, or R4 represents carboxyl when R1 and R2 are both isobutyl or R1 and R2 differently represent iso- propyl or isobutyl, the procidin occurring as a mixture of compounds when R1 and R2 are different, which process comprises cultivating Actinomadura sp. in a suitable medium and isolating the resultant pro- cidin.

416199

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