A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/44 (2006.01) C07C 271/22 (2006.01) C07C 311/16 (2006.01) C07D 211/70 (2006.01) C07D 213/56 (2006.01) C07D 213/89 (2006.01) C07D 215/48 (2006.01) C07D 215/54 (2006.01) C07D 295/155 (2006.01) C07D 307/85 (2006.01) C07D 401/00 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/00 (2006.01) C07D 409/12 (2006.01) C07D 411/00 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 421/00 (2006.01) C07D 48
Patent
CA 2332531
The present invention provides bis-aminomethyl carbonyl protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
La présente invention concerne des inhibiteurs de protéase bis-aminométhyl carbonyles et des sels, des hydrates et des solvates pharmaceutiquement acceptables de ces derniers qui inhibent les protéases, y compris la cathepsine K, des compositions pharmaceutiques de ces composés, et des procédés permettant de traiter: les affections impliquant une perte osseuse ou une dégradation du cartilage ou de la trame osseuse excessives, y compris l'ostéoporose; les atteintes gingivales, y compris la gingivite et la desmodontite; l'arthrite, et en particulier l'arthrose et la polyarthrite rhumatoïde; la maladie de Paget; l'hypercalcémie maligne; et les maladies métaboliques osseuses, lesquels procédés consistent à inhiber la perte osseuse ou la dégradation du cartilage ou de la trame osseuse excessives en administrant au patient qui en a besoin un composé de la présente invention.
Bondinell William Edward
Desjarlais Renee Louise
Veber Daniel Frank
Yamashita Dennis Shinji
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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