Protease inhibitors

Details Protease inhibitors Protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/55 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) C07C 271/12 (2006.01) C07C 271/14 (2006.01) C07D 223/04 (2006.01) C07D 223/08 (2006.01) C07D 401/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/00 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/00 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2404206

The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease; and parasitic diseases, including malaria, by administering to a patient in need thereof one or more compounds of the present invention.

L'invention concerne des inhibiteurs de protéinase alkyle C¿1?-C¿6?-4-amino-azepan-3-one et leurs sels, hydrates et solvates acceptables sur le plan pharmaceutique inhibant les protéinases, y compris cathepsine K, des compositions pharmaceutiques de ces composés, de nouveaux intermédiaires de ces composés et des procédés servant à traiter des maladies consistant en des pertes osseuses excessives ou en des dégradations de cartilage ou de matrice, y compris l'ostéoporose, des maladies gingivales, y compris la gingivite et la périodontite, l'arthrite, plus particulièrement, l'ostéoarthrite et la polyarthrite rhumatoïde, la maladie de Paget, l'hypercalcémie maligne, des maladies osseuses métaboliques, des maladies parasitaires, y compris la malaria, par administration d'un ou de plusieurs de ces composés au patient.

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