Protease inhibitors

Details Protease inhibitors Protease inhibitors

A - Human Necessities

61

K

A61K 31/34 (2006.01) A61K 31/36 (2006.01) A61K 31/38 (2006.01) A61K 31/39 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/445 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 215/14 (2006.01) C07D 231/12 (2006.01) C07D 263/32 (2006.01) C07D 277/10 (2006.01) C07D 277/66 (2006.01) C07D 285/06 (2006.01) C07D 307/80 (2006.01) C07D 317/50 (2006.01) C07D 319/20 (2006.01) C07D 333/78 (2006.01) C07D 401/12 (2006.01) C07D 409/04 (2006.01) C07D 417/12 (2006.01) C07D 495/02

Patent

CA 2335876

The present invention provides diacyl hydrazine compounds, and pharmaceutically acceptable salts, hydrates and solvates thereof, which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

L'invention porte sur des composés de diacylhydrazine et leurs sels, hydrates et solvates pharmacocompatibles inhibant les protéases, y compris la cathépsine K, sur des préparations pharmaceutiques contenant ces composés, sur de nouveaux intermédiaires de ces composés, sur des procédés de traitement des pertes osseuses excessives, ou la dégradation des matrices ou cartilages dont l'ostéoporose, les maladies gingivales dont la gingivite et la périodontite, l'arthrite et plus spécialement l'ostéoarthrite et l'arthrite chronique, la maladie de Piaget, l'hypercalcémie maligne, les troubles du métabolisme de l'os, consistant à inhiber lesdites pertes osseuses excessives, ou la dégradation des matrices ou cartilages par administration à un patient le nécessitant un des composés de la présente invention.

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