Protease inhibitors

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C - Chemistry, Metallurgy

12

N

C12N 9/99 (2006.01) A01N 43/02 (2006.01) A01N 43/06 (2006.01) A01N 43/08 (2006.01) A01N 43/16 (2006.01) A01N 43/18 (2006.01) C07D 307/00 (2006.01) C07D 307/22 (2006.01) C07D 307/32 (2006.01) C07D 307/48 (2006.01) C07D 307/83 (2006.01) C07D 307/86 (2006.01) C07D 309/00 (2006.01) C07D 309/30 (2006.01) C07D 319/06 (2006.01) C07D 321/00 (2006.01) C07D 333/02 (2006.01) C07D 333/12 (2006.01) C07D 333/22 (2006.01) C07D 335/00 (2006.01) C07D 335/02 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (

Patent

CA 2288868

The invention relates to 3-hydroxy- and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy- or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.

Cette invention se rapporte à des composés de leucine à substitution 3-hydroxy-cyclohétéro et 3-céto-cyclohétéro, qui constituent des inhibiteurs des cystéine-protéases, en particulier la cathépsine K, et qui sont utiles dans le traitement des maladies pour lesquelles l'inhibition de la déperdition osseuse constitue un facteur. La fraction 3-hydroxy ou 3-céto est liée à un cycle tétrahydrothiophène, tétrahydrothiopyranne, tétrahydrofuranne ou tétrahydropyranne.

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