Protease inhibitors as modulators of periodontal wound healing

A - Human Necessities – 61 – K

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A61K 38/57 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2389663

The invention relates to methods for regulating periodontal tissue formation, particularly periodontal tissue attachment, utilising plasminogen activator inhibitors or functional derivatives, equivalents, homologues, analogues or mimetics thereof are described. Further, the invention provides methods for the therapeutic and/or prophylactic treatment of conditions necessitating the up-regulation, inducement or other enhancement of periodontal wound healing such as gingivitis, periodontitis or following gum injuries, and compositions suitable for use in said methods.

L'invention concerne des procédés de régulation de la formation de tissus parodontaux, notamment de fixation de ceux-ci au moyen d'inhibiteurs d'activateur de plasminogène ou de leurs dérivés fonctionnels, équivalents, homologues, analogues ou mimétiques. L'invention concerne, en outre, des procédés de traitements thérapeutiques et/ou prophylactiques de conditions, tels que la gingivite, la parodontite ou des inflammations gingivales analogues, nécessitant la régulation positive, la stimulation ou d'autres améliorations de cicatrisation de plaies parodontales. L'invention porte, enfin, sur des compositions adaptées pour être utilisées dans lesdits procédés.

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