Protease inhibitors for the treatment of digestive pathologies

Details Protease inhibitors for the treatment of digestive pathologies Protease inhibitors for the treatment of digestive pathologies

A - Human Necessities

61

K

A61K 38/55 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2552638

The invention relates to compositions and methods for the treatment of intestinal pathologies. The invention also relates to compositions and methods which can be used to regulate the paracellular permeability of the intestinal epithelium. The inventive compositions and methods are based on the use of protease inhibitors which modulate the opening of the tight junctions of the intestinal epithelium. The invention can be used for preventive treatment or curative treatment of varied pathologies such as digestive functional disorders (DFD) and, in particular, intestinal functional disorders (IFD) resulting in hyperalgesia and irritable bowel syndrome (IBS) in mammals, particularly humans.

La présente demande concerne des compositions et méthodes pour le traitement de pathologies intestinales. Elle concerne également des compositions et méthodes permettant de réguler la perméabilité paracellulaire de l'épithélium intestinal. Les compositions et méthodes de l'invention reposent notamment sur l'utilisation d'inhibiteurs de protéases modulant l'ouverture des jonctions serrées de l'épithélium intestinal. L'invention est utilisable pour le traitement préventif ou curatif de pathologies variées, telles que les troubles fonctionnels digestifs (TFD) en particulier les troubles fonctionnels intestinaux (TFI) entraînant une hyperalgésie et notamment le syndrome de l'intestin irritable (SII), chez les mammifères, notamment les humains.

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