Protease resistant flint analogs

Details Protease resistant flint analogs Protease resistant flint analogs

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61P 11/00 (2006.01) C07K 14/715 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2368767

The invention relates to FLINT analogs that are resistant to proteolysis in vivo and in vitro at amino acid position 218 of mature FLINT, clinical and therapeutic uses thereof, and pharmaceutical formulations comprising said analogs.

L'invention concerne des analogues de FLINT (FAS Ligand Inhibitory proteins /protéines inhibitrices de ligands FAS), qui résistent à la protéolyse in vivo et in vitro au niveau de la position 218 de l'aminoacide du FLINT mature, des utilisations cliniques et thérapeutiques desdits analogues et des formules pharmaceutiques comprenant lesdits analogues.

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