C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2579094
The present invention relates to polypeptide variants of the HMGB-1 highaffinity binding domain Box-A (HMGB1 Box-A) or to a biologically active fragment of HMGB1 Box-A, which are obtained through systematic mutations of single amino acids of the wild-type HMGB1 Box-A protein and which show an increased resistance to proteases and which are therefore characterized by more favourable pharmacokinetic and pharmacodynamic profiles. Moreover, the present invention concerns the use of said polypeptide molecules of HMGB1 Box- A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1.
L'invention concerne des variantes polypeptidiques de séquence A du domaine de liaison à haute affinité avec la HMGB-1 (séquence A HMGB-1) ou un fragment biologiquement actif de la séquence A de la HMGB 1), qui sont obtenues par mutations systématiques d'aminoacides simples de la protéine de séquence A de HMGB 1 de type sauvage et qui manifestent une résistance accrue aux protéases et se caractérisent par conséquent par des profils pharmacocinétiques et pharmacodynamiques plus favorables. En outre, l'invention concerne l'utilisation desdites molécules peptidiques de la séquence A HMGB-1, pour diagnostiquer, atténuer et/ou traiter des pathologies associées à la HMGB-1 extracellulaire.
Barone Domenico G.
Bertarione Rava Rossa Luisa
Borrelly Gilles
Canepa Barbara
Drittanti Lila
Creabilis Therapeutics S.p.a.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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