C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/04 (2006.01) A61K 38/39 (2006.01) C07H 21/04 (2006.01) C07K 7/02 (2006.01) C07K 14/78 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2335098
The present invention relates to: manipulation of the amino acid sequence of tropoelastin, particularly human tropoelastin, to modify its protease susceptibility; to tropoelastin derivatives having modified protease susceptibility; to peptidomimetic molecules which contain amino acid sequences which correspond to or incorporate the protease susceptible sequences of tropoelastin; and to uses of the tropoelastin derivatives and peptidomimetic molecules. The invention also relates to nucleic acid molecules and genetic constructs encoding the amino acid sequences of the derivatives and peptidomimetic molecules of the invention.
La présente invention concerne: la manipulation de la séquence d'acides aminés de tropoélastine, en particulier de tropoélastine humaine, pour modifier sa sensibilité aux protéases; des dérivés de tropoélastine présentant une sensibilité aux protéases modifiée; des molécules peptidomimétiques contenant des séquences d'acides aminés correspondant aux séquences sensibles aux protéases de la tropoélastine ou les incorporant; et des utilisations de dérivés de tropoélastine et de molécules peptidomimétiques. L'invention concerne également des molécules d'acide nucléique et des produits de recombinaison génétiques codant les séquences d'acides aminés des dérivés et des molécules peptidomimétiques de l'invention.
Oyen Wiggs Green & Mutala Llp
The University Of Sydney
LandOfFree
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