Protease variants for pharmaceutical use

Details Protease variants for pharmaceutical use Protease variants for pharmaceutical use

C - Chemistry, Metallurgy

12

N

C12N 9/52 (2006.01) A61K 38/48 (2006.01) C12N 15/57 (2006.01)

Patent

CA 2707658

The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved performance in the treatment of pancreatic exocrine insufficiency (PEI). The variants may be combined with a lipase and/or an amylase. Other examples of medical indications are: Treatment of digestive disorders, pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type H.

L'invention porte sur de nouveaux variants d'une protéase provenant de Nocardiopsis sp. (SEQ ID N°1) et des protéases étroitement apparentées, ainsi que sur leur utilisation pharmaceutique. Les variants présentent une efficacité améliorée dans le traitement de l'insuffisance pancréatique exocrine (IPE). Les variants peuvent être combinés avec une lipase et/ou une amylase. D'autres exemples d'indications médicales sont : le traitement de troubles digestifs, la pancréatite, la mucoviscidose, le diabète de type I et/ou le diabète de type II.

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