C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 8/66 (2006.01) A61K 38/48 (2006.01) A61K 39/07 (2006.01) A61Q 11/00 (2006.01) A61Q 11/02 (2006.01) A61Q 19/10 (2006.01) C11D 3/386 (2006.01) C12N 9/54 (2006.01)
Patent
CA 2472206
The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins.
L'invention concerne de nouveaux variants de protéines qui présentent des réponses immunogènes réduites, comparées à des protéines parentes. L'invention concerne également des molécules d'ADN qui codent de nouveaux variants, des cellules hôtes comprenant de l'ADN codant de nouveaux variants, ainsi que des procédés de production de protéines moins allergènes. L'invention concerne, de plus, des compositions diverses comprenant lesdites protéines qui sont moins immunogènes que les protéines de type sauvage.
Estell David A.
Harding Fiona A.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Estell David A.
Genencor International Inc.
Harding Fiona A.
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