Proteasome inhibitors

Details Proteasome inhibitors Proteasome inhibitors

C - Chemistry, Metallurgy

07

D

C07D 491/044 (2006.01) A61K 31/407 (2006.01) A61K 31/655 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2723465

Disclosed herein are 6-oxa-2-az-abicyclo[3.2.0]heptane-3,7-dione or heterobicyclic .gamma.-lactam-.beta.-lactone derivatives of formula (I) that include a sulfonate ester, ester or ether group in the substituent at the 4-position as proteasome inhibitors. These Salinosporamide derivatives of formula (I) can be included in pharmaceutical compositions and can be used for treating or ameliorating a disease or condition such as cancer, a microbial disease or inflammation.

La présente invention concerne des dérivés de 6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione ou ?-lactam-ß-lactone hétérobicycliques de formule (I) qui comprennent un groupe ester de sulfonate, ester ou éther dans le substituant en position 4 en tant qu'inhibiteurs des protéasomes. Ces dérivés de salinosporamide de formule (I) peuvent être inclus dans des compositions pharmaceutiques et peuvent être utilisés pour traiter et/ou améliorer une maladie ou une pathologie telle que le cancer, une maladie microbienne et/ou une inflammation.

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