Proteasome inhibitors and methods of using the same

Details Proteasome inhibitors and methods of using the same Proteasome inhibitors and methods of using the same

C - Chemistry, Metallurgy

07

F

C07F 5/04 (2006.01) A61K 31/69 (2006.01) A61P 35/00 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2536518

The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

La présente invention concerne des composés d'acide boronique, des esters boroniques et des compositions obtenues à partir de ces composés qui permettent de moduler l'apoptose par inhibition de l'activité du protéasome. Ces composés et compositions s'utilisent avec des méthodes destinées à induire une apoptose et à traiter des maladies telles que le cancer et autres pathologies en rapport direct ou indirect avec l'activité du protéasome.

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