Proteasome inhibitors and methods of using the same

Details Proteasome inhibitors and methods of using the same Proteasome inhibitors and methods of using the same

C - Chemistry, Metallurgy

07

F

C07F 5/02 (2006.01) A61K 31/69 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2535686

The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

L'invention concerne des composés d'acide boronique, des esters boroniques et des compositions de ceux-ci qui permettent de moduler l'apoptose, p. ex. par l'inhibition de l'activité protéasomique. Ces composés et compositions peuvent être utilisés dans des procédés visant à induire l'apoptose et à traiter des maladies telles que le cancer et d'autres troubles associés directement ou indirectement l'activité protéasomique.

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