Proteasome inhibitors, ubiquitin pathway inhibitors or...

Details Proteasome inhibitors, ubiquitin pathway inhibitors or... Proteasome inhibitors, ubiquitin pathway inhibitors or...

A - Human Necessities

61

K

A61K 31/69 (2006.01) A61K 31/16 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2304622

This invention is directed to the treatment of inflammatory and autoimmune diseases by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF-B via the ubiquitin proteasome pathway, or mixtures thereof. The invention is further directed to the treatment of inflammatory and autoimmune diseases by administering an effective combination of a glucocorticoid and a proteasome inhibitor, ubiquitin pathway inhibitor, agent that interferes with the activation of NF-B via the ubiquitin proteasome pathway, or mixture thereof. Pharmaceutical compositions comprising a combination of a glucocorticoid and a proteasome inhibitor, ubiquitin pathway inhibitor, agent that interferes with the activation of NF-B via the ubiquitin proteasome pathway, or mixture thereof are also contemplated within the scope of the invention.

Cette invention a trait au traitement de maladies inflammatoires et autoimmunes par l'administration d'inhibiteurs de protéasome, d'inhibiteurs des voies de l'ubiquitine, des agents entravant l'activation de NF-?B via les voies de l'ubiquitine protéasome, ou des mélanges de ceux-ci. L'invention a également trait au traitement de maladies inflammatoires et autoimmunes par l'administration d'une combinaison efficace d'un glucocorticoïde et d'un inhibiteur de protéasome, un inhibiteur des voies de l'ubiquitine, un agent entravant l'activation de NF-?B via les voies de l'ubiquitine protéasome, ou un mélange de ceux-ci. L'invention a également trait à des compositions pharmaceutiques comprenant une combinaison d'un glucocorticoïde et d'un inhibiteur de protéasome, d'un inhibiteur des voies de l'ubiquitine, un agent entravant l'activation de NF-?B via les voies de l'ubiquitine protéasome, ou bien un mélange de ceux-ci.

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