Protected aminothiazolylacetic acid derivatives

Details Protected aminothiazolylacetic acid derivatives Protected aminothiazolylacetic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/42 (2006.01) C07D 277/20 (2006.01) C07D 417/12 (2006.01) C07D 501/00 (2006.01)

Patent

CA 2145012

Described is a protected aminothiazolylacetic acid derivative represented by the following formula (I): Image wherein A represents a nitrogen atom or a methine group, R1 and R2 may be the same or different and individually represent a hydrogen atom, a lower alkyl group or a substituted or unsubstituted aryl group, R3 represents a lower alkoxy group, a halogenated lower alkoxy group, a triphenylmethoxy group, a lower alkyl group or an acyloxy group, and R4 represents a halogen atom, a hydroxy group, a lower alkoxy group or a substituted or unsubstituted amino group; and salts thereof; as well as processes for the preparation thereof. The protected aminothaizolylacetic acid derivative according to the present invention is an useful intermediate for introducing a 2-(2-aminothiazol-4-yl)-2-alkoxyiminoacetyl group or a 2-(2-aminotiazol-4-yl)-2-alkenoyl group into a cephem skeleton.

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