C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/136, 167/318
C12P 21/00 (2006.01) A61K 35/74 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/09 (2006.01) C12P 1/04 (2006.01)
Patent
CA 1130726
ABSTRACT An antigenic protein, termed antigen A, present on the cell walls and in cultures of Streptococcus mutans, especially genetic group I (serotypes c, e and f) is separated from other antigenic proteins, notable those which cross-react with heart tissue, to give an antigenic preparation which may be used as a vaccine or to raise antibodies for use in protecting against dental caries. Antigen A is one of two major antigenic proteins remaining on cell walls of S. mutans genetic group I after extraction with a boiling 10 litre aqueous solution of sodium dodecyl sulphate for 20 minutes. It has a molecular weight of about 29,000, an isoelectric point of 4.1 to 4.5. Its amino-acid analysis is also given. The antigen also occurs in the culture filtrate and/or cell extract and may be readily purified from these sources by, for example fractional ammonium sulphate precipitation and/or affinity chromatography on immobilised antibody.
334333
Colman Geoffrey
Russell Roy R.b.
Gowling Lafleur Henderson Llp
Secretary Of State For Social Services In Her Britannic Majesty'
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