C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/135
C12P 21/00 (2006.01) A61K 39/09 (2006.01) A61K 39/39 (2006.01) A61K 39/40 (2006.01)
Patent
CA 1204384
ABSTRACT PROTECTION AGAINST DENTAL CARIES An antigenic protein, termed antigen C, present on the cell wall and in cultures of Streptococcus mutans, espe- cially genetic group I (serotypes c, e and f) is separated from other antigenic proteins, notably those which cross react with heart tissue, to give an antigen preparation which may be used as a vaccine or to raise antibodies for use in protec- ting against dental caries. Antigen C is destroyed or extracted from the cell walls by treatment with boiling aqueous sodium dodecyl sulphate (10 gm per litre) for 10 minutes. It has a molecular weight of 70,000 ? 5,000 and an isoelectric point of 4.45 ? 0.24. It is destroyed by proteolytic enzyme and does not cross react with heart tissue. The antigen also occurs in the culture filtrate and/or cell extract and may readily be separated from these sources by affinity chromatography on immobilised antibody.
405224
Fetherstonhaugh & Co.
Secretary Of State For Social Services In Her Britannic Majesty'
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