Protection of hemopoietic cells during chemotherapy or...

A - Human Necessities – 61 – K

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A61K 38/19 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/18 (2006.01) A61K 38/20 (2006.01)

Patent

CA 2199730

A method of promoting regeneration of hemopoietic cells in a subject undergoing chemotherapy or radiotherapy, which method includes the steps of (i) administering to the subject a first amount of a hemopoiesis inhibitory factor, the first amount being effective to reduce the proliferation of hemopoietic cells during the chemotherapy or radiotherapy; and (ii) after the chemotherapy or radiotherapy, administering to the subject a second amount of a hemopoiesis growth factor, the second amount being effective to stimulate the proliferation of hemopoietic cells.

Procédé permettant de stimuler la régénération de cellules hématopoïétiques chez un sujet soumis à une chimiothérapie ou à une radiothérapie, et consistant (i) à administrer au sujet une première quantité d'un facteur inhibiteur d'hématopoïèse, cette première quantité étant suffisante pour réduire la prolifération des cellules hématopoïétiques pendant la chimiothérapie ou la radiothérapie; et (ii) à administrer audit sujet, après le traitement par chimiothérapie ou radiothérapie, une deuxième quantité d'un facteur stimulant l'hématopoïèse, cette deuxième quantité étant suffisante pour stimuler la prolifération des cellules hématopoïétiques.

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