A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/661 (2006.01) A61K 31/00 (2006.01) A61K 31/66 (2006.01) A61K 31/685 (2006.01) A61K 31/688 (2006.01) A61P 15/08 (2006.01)
Patent
CA 2400405
Described are methods for protecting the female reproductive system against natural and artificial insults by administering to women a composition comprising an agent that antagonizes one or more acid sphingomyelinase (ASMase) gene products. Specifically, methods disclosed herein serve to protect women's germline from damage resulting from cancer therapy regimens including chemotherapy or radiotherapy. In one aspect, the method preserves, enhances, or revives ovarian function in women, by administering to women a composition containing sphingosine-1-phosphate, or an analog thereof. Also disclosed are methods to prevent or ameliorate menopausal syndromes and to improve in vitro fertilization techniques.
L'invention concerne des méthodes de protection de l'appareil reproducteur féminin contre des agressions naturelles et artificielles, consistant à administrer à des femmes une composition renfermant un agent qui constitue un antagoniste à au moins un produit génétique de sphingomyélinase acide (ASMase). Notamment, les méthodes de ladite invention servent à protéger la lignée germinale des femmes de dommages occasionnés par des régimes thérapeutiques pour le cancer, y compris la chimiothérapie ou la radiothérapie. Selon un aspect, la méthode permet de préserver, d'améliorer, ou de ranimer la fonction des ovaires chez des femmes, par administration d'une composition contenant du sphingosine-1-phosphate, ou un analogue correspondant. Cette invention concerne aussi des méthodes de prévention ou d'amélioration des syndromes ménopausiques et d'amélioration des techniques de fertilisation in vitro.
Kolesnick Richard N.
Tilly Jonathan L.
Massachusetts General Hospital
Sloan-Kettering Institute For Cancer Research
Smart & Biggar
LandOfFree
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