Protective effect of high dose folate on mycardial ischemia

A - Human Necessities – 61 – K

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A61K 31/519 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2713377

The present invention relates to the use of high dose of folic acid, or an equivalent dose one of its biological active derivatives to blunt myocardial dysfunction during ischemia and to ameliorate post-reperfusion injury. The invention specially re-lates to an early treatment by the application of a high dose of at least 200mg folic acid, or an equivalent dose of a derivative dur-ing active ischemia, before the reperfusion.

La présente invention concerne l'utilisation d'une dose élevée d'acide folique, ou d'une dose équivalente d'un de ses dérivés biologiquement actifs pour atténuer la dysfonction myocardique durant une ischémie et améliorer la lésion de reperfusion. L'invention concerne spécialement un traitement précoce par l'administration d'une dose élevée d'au moins 200 mg d'acide folique, ou d'une dose équivalente d'un dérivé durant une ischémie active, avant la reperfusion.

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