Protective gel based on chitosan and oxidized polysaccharide

Details Protective gel based on chitosan and oxidized polysaccharide Protective gel based on chitosan and oxidized polysaccharide

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 31/717 (2006.01) A61K 31/718 (2006.01) A61K 31/722 (2006.01)

Patent

CA 2721937

Bodily tissue and structures may be protected using a fluid layer containing a mixture of chitosan and oxidized polysaccha-ride. The mixture forms a protective gel layer via in situ crosslinking. Compared to crosslinking using a low molecular weight aldehyde such as glutaraldehyde or genipin, oxi-dized polysaccharides appear to pro-vide faster gelation while avoiding the use of potentially less bioaccept-able low molecular weight aldehydes.

Selon la présente invention, un tissu et des structures corporels peuvent être protégés en utilisant une couche de fluide contenant un mélange de chitosane et de polysaccharide oxydé. Le mélange forme une couche de gel protecteur par réticulation in situ. Par rapport à la réticulation utilisant un aldéhyde de faible poids moléculaire tel que le glutaraldéhyde ou la génipine, il apparaît que les polysaccharides oxydés permettent une gélification plus rapide tout en évitant lutilisation daldéhydes de faible poids moléculaire potentiellement moins biologiquement acceptables.

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