Protective peptides derived from human immunodeficiency...

C - Chemistry – Metallurgy – 07 – K

Patent

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530/7.04, 530/15

C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 14/705 (2006.01) C07K 16/10 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1341391

A peptide comprising an amino acid sequence of up to 50 amino acids that corresponds to at least a port ion of a protective epitope of HIV and includes an amino acid sequence chosen from the group consisting of:- (a) gly-glu-ile-lys-asn-cys-ser-phe-asn-ile-ser-thr- ser-ile-arg-gly-lys-val-gln-lys-glu-tyr-ala; (b) asn-gly-asn-ala-glu-glu-val-val-ile-arg-ser-ala- asn-phe-thr-asp-asn -ala-lys-thr-ile-ile-val; (c) cys-asn-ile-ser-arg-ala-Lys-trp-asn-asn-thr-leu- lys-gln-ile-asp-ser-lys-leu-arg-glu-gln-phe; (d) gly-ser-asp-thr-ile-thr-leu-pro-cys-arg-ile-lys- gln-ile-ile-asn-met-trp-gln-glu-val-gly-lys ; and (e) val-gln-gln-gln-asn-asn-leu-leu-arg-ala-thr-glu- ala-gln-his-leu-leu-gln-leu-thr-val-thp-gly-ile-lys- gln-leu-gln. The disclosed peptides are immunologically cross-reactive with human immunodeficiency virus 41,000 dalton glycoprotein gp41. These novel peptides are useful in methods of interfering with the effects of HIV-1 upon host cells having cell surface polypeptides capable of binding HIV-1.

597209

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