Protein a based binding domains with desirable activities

Details Protein a based binding domains with desirable activities Protein a based binding domains with desirable activities

A - Human Necessities

61

K

A61K 39/085 (2006.01) A61K 45/00 (2006.01) C07K 14/31 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2374013

Provided are Staphylococcal protein A (SpA) variants for binding immunoglobulin (Ig), comprising a polypeptide which varies by one or more amino acids from the amino acid sequence of a natural variable heavy chain III ("VH3") Ig-Fab binding region ("binding region") of SpA, wherein the polypeptide exhibits a different binding specificity for Ig-Fab than does SpA or exhibits a different binding specificity for a non-Ig target molecule than does SpA. Further provided are methods of making the variants and methods of using the variants for in purification of Ig as well as diagnostic and therapeutic intervention.

L'invention concerne des variants protéiques staphylococciques A (SpA) de liaison de l'immunoglobuline (Ig), qui comprennent un polypeptide qui varie d'au moins un acide aminé à partir de la séquence d'acide aminé d'une région de fixation ("région de fixation") Ig-Fab à chaîne III lourde variable naturelle ("VH3") de la SpA. Le polypeptide présente une spécificité de liaison pour Ig-Fab différente de celle de la SpA ou une spécificité de liaison pour une molécule cible non-Ig différente de celle de la SpA. L'invention traite en outre de procédés de fabrication des variants et de leurs procédés d'utilisation pour la purification de Ig et en tant qu'intervention thérapeutique et de diagnostic.

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