Protein a perfusion and postperfusion drug infusion

Details Protein a perfusion and postperfusion drug infusion Protein a perfusion and postperfusion drug infusion

G - Physics

01

N

167/114, 167/139

G01N 33/543 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61M 1/34 (2006.01) A61M 1/36 (2006.01)

Patent

CA 1197460

ABSTRACT OF THE DISCLOSURE Disclosed is extracorporeal plasma perfusion over a therapeutic immobilized protein A (staphylococcal), SPA. The perfused plasma is returned to the host or can be taken off one person and used to treat another and stored in perfused plasma banks. Immobilized protein A quantities, volumes of plasma perfused and the rate of administration based on clinical and toxicity evaluations are set forth. A non-toxic drug infusion during the immediate postperfusion period obtains an observed tumoricidal response far exceeding those due to the extracorporeal plasma perfusion or drug infusion alone representing an in vivo synergism between the perfused plasma and the drug. Also disclosed are the therapeutic protein A cartridge, its loading and delivery system, and a miniaturized immunoabsorbent apparatus enabling the processing of serum samples for testing small quanitities of plasma. The government has rights in these inventions pursuant to U.S. Public Health Service Grants or Awards 5K04AI00302 and 5R01GM23517.

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