Protein allergen derivatives

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/415 (2006.01) A61K 38/16 (2006.01)

Patent

CA 2589187

The present invention relates to a method for producing derivatives of wild- type protein allergens with reduced allergenic activity, characterized in by the following steps: providing a wild-type protein allergen with an allergenic activity, splicing said wild-type protein allergen into two parts, said two parts having a reduced allergenic activity or lacking allergenic activity and rejoining said two fragments in inverse orientation; as well as allergen derivatives.

L'invention concerne une méthode pour produire des dérivés d'allergènes protéiniques de type sauvage présentant une activité allergène réduite. Cette méthode est caractérisée par les étapes consistant à: fournir un allergène protéinique de type sauvage présentant une activité allergène, épisser cet allergène protéinique de type sauvage en deux parties, ces deux parties présentant une activité allergène réduite ou une activité allergène manquante, et réassembler les deux fragments dans une orientation inverse. L'invention concerne également les dérivés d'allergènes associés.

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