Protein- and peptide-metal ion pharmaceutical applications

Details Protein- and peptide-metal ion pharmaceutical applications Protein- and peptide-metal ion pharmaceutical applications

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 49/00 (2006.01) A61K 49/08 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C07K 1/13 (2006.01) C07K 5/083 (2006.01) C07K 7/06 (2006.01) C07K 14/52 (2006.01) C07K 14/655 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01) A61K 43/00 (1990.01)

Patent

CA 2127284

Peptides containing a biological-function domain and a medically useful metal ion-binding domain and proteins contain- ing monosulfide or disulfide bonds are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of pathologic conditions. The peptides have the amino acid sequence (R1)-[Y1]n- (R2), (R1)-[Y1-(R2)-Y1]n-(R3), and (R1)-[Y1-(R2)-Y2]n-(R3), with the biological-function domain optionally containing the sequence IKVAV and YIGSR. The medically useful metal ion-binding domain is [Y1]n, [Y1-(R2)-Y1]n or [Y1-(R2)- Y1]n. Sn(II) agents are used to label the pro- teins with medically useful metal ions.

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